Patients with diseases involving the anterior pituitary gland often have gonadotropin deficiency. Thus, the disappearance of menstrual periods may be the first sign of a pituitary tumour or other pituitary disease in women. In men the most common symptoms of gonadotropin deficiency are loss of libido and erectile dysfunction . Isolated deficiencies of both LH and FSH do occur but only rarely. In men isolated LH deficiency (“fertile eunuch”) is characterized by symptoms and signs of androgen deficiency; however, there is sufficient secretion of FSH to permit the maturation of spermatozoa. Some pituitary tumours produce an excess of LH or FSH, whereas other pituitary tumours produce the hormonally inactive alpha chain subunit of the glycoprotein hormones.
Frequency not reported: Large ovarian cysts (prone to rupture), mild ovarian hyperstimulation syndrome (OHSS), mild to moderate enlargement of ovaries, ovarian cysts, painful breasts, severe OHSS, unwanted ovarian hyperstimulation
Common (1% to 10%): Dysmenorrhea, intermenstrual bleeding, ovarian cyst, ovarian hyperstimulation, mild/moderate OHSS
Uncommon (% to 1%): Breast pain, severe OHSS
Frequency not reported: Adnexal torsion, albuminuria, cervical lesion, dysuria , ectopic pregnancy , genital herpes, genital moniliasis, leukorrhea, mild to moderate ovarian enlargement, ovarian enlargement, ovarian torsion, postpartum fever, urinary incontinence , urinary tract infection, uterine disorders, vaginal discomfort, vaginal hemorrhage, vaginitis [ Ref ]