In 2014, The FDA notified Ranbaxy Laboratories, Ltd., that it is prohibited from manufacturing and distributing active pharmaceutical ingredients (APIs) from its facility in Toansa, India, for FDA-regulated drug products. The FDA's inspection of the Toansa facility, which concluded on January 11, 2014, identified significant CGMP violations. These included Toansa staff retesting raw materials, intermediate drug products, and finished API after those items failed analytical testing and specifications, in order to produce acceptable findings, and subsequently not reporting or investigating these failures.  
Highly effective for actual pain relief is the herbal devil's claw, found in Joint Renew II. It can also be added separately from products like Nature's Own B-L Solution (combination of yucca and devil's claw) or Uckele's Devil's Claw Plus, with devil's claw, yucca, bromelain and other anti-inflammatory herbs. An especially effective combination product is Uckele's Arthrigen, a mix of glucosamine, chondroitin, hyaluronic acid at higher dose than other combo products, devil's claw, bromelain and other antioxidants vitamins and minerals.