Haloperidol decanoate side effects

CNS depression potentiated with alcohol, other CNS depressants. Possible neurotoxicity with lithium: monitor, discontinue if occurs. Caution with drugs that prolong the QT interval (eg, ketoconazole, paroxetine). May be potentiated by CYP3A4 or CYP2D6 inhibitors/substrates (eg, itraconazole, nefazodone, buspirone, venlafaxine, alprazolam, fluvoxamine, quinidine, fluoxetine, sertraline, chlorpromazine, promethazine. May be antagonized by CYP3A4 inducers (eg, rifampin, carbamazepine); monitor and adjust doses. May increase intraocular pressure with anticholinergics, antiparkinson agents. Monitor anticoagulants.

Fluphenazine came into use in 1959. [6] The injectable form is on the World Health Organization's List of Essential Medicines , the most effective and safe medicines needed in a health system . [7] It is available as a generic medication . [1] In the United States the tablets costs between and USD per day for a typical dose. [1] The wholesale cost in the developing world of the long acting form is between and USD per injection as of 2014. [8] It was discontinued in Australia around mid 2017. [9]

Haldol is available in sterile vials containing 5 mg strength Haldol per 1 ml of fluid used for injection. Usual starting dose is -5 mg intramuscularly. Dose may vary according to patient response to the drug. Switch to an oral form of this drug is recommended as soon as possible. Haldol may interact with other drugs so the patient needs close observation or monitoring to determine if other side effects develop. Haldol should only be used during pregnancy or in women likely to become pregnant only if the benefit clearly justifies a potential risk to the fetus; fetal abnormalities and fetal exposure to Haldol in the third trimester have shown dependence at birth. Women who are breastfeeding should not take Haldol because the drug may affect the infant. Although reports of use for behavior modification exist, the drug is not approved for use in children.

Common adverse effects of Haldol usually include sleepiness, dizziness, rapid heart beat, constipation, excess saliva production and weight gain. Another important adverse effect that occurs commonly is orthostatic hypotension (a lowering of your blood pressure when you are sitting up or standing up). Occasionally this can lead to fainting and falling down, therefore, people taking Haldol should be careful when they change positions. These adverse effects are usually mild and usually go away after the first several days of starting treatment or increasing a dose.

The dose of Haldol Decanoate 50 or Haldol Decanoate 100 should be expressed in terms of its haloperidol content. The starting dose of haloperidol decanoate should be based on the patient's age, clinical history, physical condition, and response to previous antipsychotic therapy. The preferred approach to determining the minimum effective dose is to begin with lower initial doses and to adjust the dose upward as needed. For patients previously maintained on low doses of antipsychotics (. up to the equivalent of 10 mg/day oral haloperidol), it is recommended that the initial dose of haloperidol decanoate be 10–15 times the previous daily dose in oral haloperidol equivalents; limited clinical experience suggests that lower initial doses may be adequate.

Haloperidol decanoate side effects

haloperidol decanoate side effects

Common adverse effects of Haldol usually include sleepiness, dizziness, rapid heart beat, constipation, excess saliva production and weight gain. Another important adverse effect that occurs commonly is orthostatic hypotension (a lowering of your blood pressure when you are sitting up or standing up). Occasionally this can lead to fainting and falling down, therefore, people taking Haldol should be careful when they change positions. These adverse effects are usually mild and usually go away after the first several days of starting treatment or increasing a dose.

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