Diclofenac belongs to a class of drugs called nonsteroidal anti-inflammatory drugs ( NSAIDs ) that are used for the treatment of mild to moderate pain , fever , and inflammation. Other members of this class include ibuprofen ( Motrin ), indomethacin ( Indocin ), nabumetone (Relafen), naproxen ( Aleve ) and several others. NSAIDs work by reducing the production of prostaglandins, chemicals that cause pain , fever and inflammation. NSAIDs block the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower production of prostaglandins. As a consequence, inflammation, pain and fever are reduced. Since the response to different NSAIDs varies from patient to patient, it is not unusual for a doctor to try different NSAIDs for any given condition. The FDA approved diclofenac in July 1998.
For the relief of osteoarthritis, the recommended dosage of Voltaren (diclofenac) is 100-150 mg/day in divided doses (50 mg twice a day or three times a day, or 75 mg twice a day). For the relief of rheumatoid arthritis, the recommended dosage of Voltaren (diclofenac) is 150-200 mg/day in divided doses (50 mg three times a day. or four times a day, or 75 mg twice a day.). For the relief of ankylosing spondylitis, the recommended dosage of Voltaren (diclofenac) is 100-125 mg/day, administered as 25 mg four times a day, with an extra 25-mg dose at bedtime if necessary. Voltaren should be taken with food to reduce stomach upset. Voltaren may interact with antidepressants, blood thinners, cyclosporine, isoniazid, lithium, methotrexate, pronbenecid, rifampin, secobarbital, sertraline, sulfamethoxazole, teniposide, zafirlukast, diuretics (water pills), steroids, antifungal medications, aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs), cholesterol-lowering medicines, or heart or blood pressure medications. Tell your doctor all medications and supplements you use. Like other NSAIDs, Voltaren is generally avoided during pregnancy because it may affect the cardiovascular system of the fetus. It is not known whether Voltaren is excreted in breast milk.
In addition to glabellar lines, Botox is used to eradicate crow’s feet, frown lines and furrows in the forehead. Whereas treating crow's feet with Botox was for many years an off-label use, the toxin got the official FDA nod for treating crow's feet in late 2013. Botox is also approved to treat a variety of medical conditions, including ocular muscle spasms, problems with eye coordination, severe armpit perspiration, migraine headaches, overactive bladder, urinary incontinence related to nerve damage from conditions such as multiple sclerosis and spine injury. Botox is being studied to determine if it might be useful in treating conditions such as knee and hip osteoarthritis, temporomandibular joint disorder (TMJ) and benign prostatic hyperplasia (BPH).