Male sex hormone

There is considerable controversy over the earliest age at which it is clinically, morally, and legally safe to use GnRH analogues, and for how long. The sixth edition of the World Professional Association for Transgender Health 's Standards of Care permit it from Tanner stage 2 but do not allow the addition of hormones until age 16, which could be five or more years later. Sex steroids have important functions in addition to their role in puberty, and some skeletal changes (such as increased height) that may be considered masculine are not hindered by GnRH analogues.

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Dihydrotestosterone (DHT) (referred to as androstanolone or stanolone when used medically) can also be used in place of testosterone as an androgen. The availability of DHT is limited; it is not available in the United States or Canada, for instance, but it is available in certain European countries, including the United Kingdom , France , Spain , Belgium , Italy , and Luxembourg . [5] DHT is available in formulations including topical gel, buccal or sublingual tablets, and as esters in oil for intramuscular injection. [6] Relative to testosterone, and similarly to many synthetic AAS, DHT has the potential advantages of not being locally potentiated in so-called androgenic tissues that express 5α-reductase (as DHT is already 5α-reduced) and of not being aromatized into an estrogen (it is not a substrate for aromatase).

Dr. Min Lee, program officer on the upcoming trial and a researcher at the National Institute of Child Health and Human Development, says that the contraceptive gel contains much less synthetic testosterone than the injectable formula did—which will hopefully prevent many of those problems. “If we stop the production of testosterone, men are obviously going to experience side effects beyond just their sperm count,” he says. “But we’re only adding back just enough so they have normal physiological responses, not the huge amount that’s been used in other formulations.”

Currently, the SHBG test is not performed frequently or routinely. In many cases, health practitioners feel that the total testosterone , and perhaps free testosterone (as measured by a method called equilibrium dialysis), provides sufficient information. SHBG is ordered primarily when the total testosterone results do not seem to be consistent with clinical signs and symptoms , such as infertility, decreased sex drive, and erectile dysfunction in men or infertility , irregular menstrual periods, and excess facial and body hair in women.

Male sex hormone

male sex hormone

Dr. Min Lee, program officer on the upcoming trial and a researcher at the National Institute of Child Health and Human Development, says that the contraceptive gel contains much less synthetic testosterone than the injectable formula did—which will hopefully prevent many of those problems. “If we stop the production of testosterone, men are obviously going to experience side effects beyond just their sperm count,” he says. “But we’re only adding back just enough so they have normal physiological responses, not the huge amount that’s been used in other formulations.”

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