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Dienogest was synthesized in 1979 in Jena , Germany under the leadership of Kurt Ponsold, was initially referred to as STS-557 . [30] [31] It was found that its potency was 10 times that of levonorgestrel . [32] The first product on the market to contain dienogest was a combined oral contraceptive pill (with ethinylestradiol), Valette, introduced in 1995 and made by Jenapharm . [33] In 2007, dienogest was introduced as Dinagest in Japan for the treatment of endometriosis, and it was subsequently marketed for this indication as Visanne in Europe and Australia in December 2009 and April 2010, respectively. [8] Qlaira was introduced in Europe in 2009 and Natazia was introduced in the United States in 2010. [34]

Addiction to cortisone was the subject of the 1956 motion picture, Bigger Than Life , produced by and starring James Mason . Though it was a box-office flop upon its initial release, [15] many modern critics hail it as a masterpiece and brilliant indictment of contemporary attitudes towards mental illness and addiction. [16] In 1963, Jean-Luc Godard named it one of the ten best American sound films ever made. [17] John F. Kennedy needed to regularly use corticosteroids such as cortisone as a treatment for Addison's disease . [18]

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