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Catrina made it clear that this project was not at all about failure of current spandrel beams. Current slender spandrel beams were actually overly reinforced and, therefore, were not as cost effective as they could be, although they were as safe then as they are now with the new design guidelines in place. She goes on to explain that during the research project, the full-scale spandrel beam specimens were overloaded until they failed so that the failure mechanism could be identified. Spandrels would not be loaded to such an extreme degree in a real-life situation.

In 1978 FDA published a tentative final monograph (TFM) for topical antimicrobial products. The record was re-opened in March 1979 to take into account six comments the agency received during the period for submitting objections to the TFM, including new data submitted by Procter & Gamble on the safety and effectiveness of triclocarban and by Ciba-Geigy on the proliferation of use of triclosan. The document states that, “significant amounts of new and previously unconsidered data were submitted with each of the above petitions.” [69] It was re-opened again in October of that year to permit interested persons to submit further data establishing conditions for the safety, effectiveness and labeling of over-the-counter topical antimicrobial products for human use.

Decanoic acid acts as a non-competitive AMPA receptor antagonist at therapeutically relevant concentrations, in a voltage- and subunit-dependent manner, and this is sufficient to explain its antiseizure effects. [13] This direct inhibition of excitatory neurotransmission by decanoic acid in the brain contributes to the anticonvulsant effect of the MCT ketogenic diet . [13] Decanoic acid and the AMPA receptor antagonist drug perampanel act at separate sites on the AMPA receptor, and so it is possible that they have a cooperative effect at the AMPA receptor, suggesting that perampanel and the ketogenic diet could be synergistic. [13]

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