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Study Name : NCT00642707
Phase : IIa
Status : This study has been completed.
Location : United States
Purpose : The purpose of this study was to look at the effectiveness, safety, and drug properties of different doses of PRO-140 and compare PRO-140 to a placebo . (A placebo is an inactive drug that is identical in appearance to the active drug being studied.) PRO-140 was given without any other HIV medicines (also known as monotherapy ) and by subcutaneous infusion . (A subcutaneous infusion is an injection placed under the skin to deliver a drug or other fluids over a period of time.) 8,9

Study Names : (1) PRO 140_CD 01; NCT02175680 and (2) PRO 140_CD 01-Extension; NCT02355184
Phase : IIb
Status : (1) PRO 140_CD 01 has been completed and (2) PRO 140_CD 01-Extension is ongoing, but not recruiting participants.
Location : United States
Purpose : The purpose of the PRO 140_CD 01 study was to evaluate whether certain individuals who already had undetectable viral loads could take a planned temporary break from their daily ART by using PRO-140 to maintain viral suppression . The PRO 140_CD 01-Extension study is evaluating the long-term effectiveness and safety of taking only PRO-140 for HIV treatment. 10-12

Study Names : (1) PRO 140_CD 02; NCT02483078 and (2) PRO 140_CD 02 Extension; NCT02990858
Phase : IIb/III
Status : (1) PRO 140_CD 02 is ongoing, but not recruiting participants and (2) PRO 140_CD 02 Extension is enrolling participants by invitation.
Location : United States and Puerto Rico
Purpose : The purpose of this study is to look at the safety and effectiveness of using PRO-140 with a failing ART regimen for 1 week and then using PRO-140 with an optimized ART regimen for 24 weeks. (An optimized ART regimen is a combination of drugs chosen on the basis of a person’s resistance test results and treatment history.) PRO 140_CD 02 Extension is designed to provide eligible participants with continued access to PRO-140. 4,13

Study Names : PRO 140_CD03; NCT02859961
Phase : IIb/III
Status : This study is currently recruiting participants.
Location : United States
Purpose : The purpose of this study is to evaluate the safety and effectiveness of PRO-140 monotherapy for the maintenance of viral suppression over 48 weeks. 7
For more details on the studies listed above, see the Health Professional version .

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