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Nonparametric confidence limits are obtained by calculating upper and lower percentiles of the B concentrations for each time. For example, if B = 1000, the 95% confidence interval of for concentration calculated from the original Theil-Sen line is obtained from the 25th largest concentration ( percentile) and 975th largest concentration ( percentile) of the B bootstrap A computerized method for assigning measures of accuracy to sample estimates. This technique allows estimation of the sample distribution of almost any statistic using only very simple methods. Bootstrap methods are generally superior to ANOVA for small data sets or where sample distributions are nonnormal (USEPA 2010). concentrations.